Findings show that impaired autophagy leads to muscle degeneration, inflammation, and mitochondrial defects, while ...

Silencing mRNA expression in dendritic cells did not impair T‑cell priming, including for SARS‑CoV‑2 antigens, suggesting that cross‑presentation by other cell types is sufficient to initiate immunity ...

Myofibrillar myopathy type 6 (MFM6) is a rare genetic muscle disorder that leads to severe muscle weakness and a drastically shortened life expectancy due to a disruption in muscle protein regulation.

Researchers developed human muscle models that demonstrate human-like functional and molecular responses to pharmaceutical ...

For nearly 25 years, scientists believed they knew what caused the most severe form of narcolepsy. A new UCLA Health study ...

A series of recent physiology studies span from rare disease mechanisms to space-based biomedical advances. Findings include ...

Researchers at the University Hospital Bonn have developed a humanized mouse model for myofibrillar myopathy type 6 (MFM6), revealing that impaired autophagy driven by a defective BAG3 protein leads ...

Enzo Porrello’s eyes light up and he leans in, radiating enthusiasm as he describes the first time he saw lab-created heart ...

Stroke remains a leading cause of death and long-term disability worldwide, largely due to severe damage to the neurovascular ...

The Greenland shark (Somniosus microcephalus), with an expected lifespan of up to 400 years, is the longest-living known ...